Cellular scent of influenza virus infection.
Identifieur interne : 000F54 ( Main/Exploration ); précédent : 000F53; suivant : 000F55Cellular scent of influenza virus infection.
Auteurs : Alexander A. Aksenov [États-Unis] ; Christian E. Sandrock ; Weixiang Zhao ; Shankar Sankaran ; Michael Schivo ; Richart Harper ; Carol J. Cardona ; Zheng Xing ; Cristina E. DavisSource :
- Chembiochem : a European journal of chemical biology [ 1439-7633 ] ; 2014.
Descripteurs français
- KwdFr :
- Chromatographie gazeuse-spectrométrie de masse, Composés organiques volatils (analyse), Composés organiques volatils (métabolisme), Grippe humaine (anatomopathologie), Grippe humaine (métabolisme), Grippe humaine (virologie), Humains, Lignée cellulaire, Lymphocytes B (cytologie), Lymphocytes B (métabolisme), Lymphocytes B (virologie), Marqueurs biologiques (métabolisme), Sous-type H1N1 du virus de la grippe A (métabolisme), Sous-type H9N2 du virus de la grippe A (métabolisme).
- MESH :
- analyse : Composés organiques volatils.
- anatomopathologie : Grippe humaine.
- cytologie : Lymphocytes B.
- métabolisme : Composés organiques volatils, Grippe humaine, Lymphocytes B, Marqueurs biologiques, Sous-type H1N1 du virus de la grippe A, Sous-type H9N2 du virus de la grippe A.
- virologie : Grippe humaine, Lymphocytes B.
- Chromatographie gazeuse-spectrométrie de masse, Humains, Lignée cellulaire.
English descriptors
- KwdEn :
- B-Lymphocytes (cytology), B-Lymphocytes (metabolism), B-Lymphocytes (virology), Biomarkers (metabolism), Cell Line, Gas Chromatography-Mass Spectrometry, Humans, Influenza A Virus, H1N1 Subtype (metabolism), Influenza A Virus, H9N2 Subtype (metabolism), Influenza, Human (metabolism), Influenza, Human (pathology), Influenza, Human (virology), Volatile Organic Compounds (analysis), Volatile Organic Compounds (metabolism).
- MESH :
- chemical , analysis : Volatile Organic Compounds.
- chemical , metabolism : Biomarkers, Volatile Organic Compounds.
- cytology : B-Lymphocytes.
- metabolism : B-Lymphocytes, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H9N2 Subtype, Influenza, Human.
- pathology : Influenza, Human.
- virology : B-Lymphocytes, Influenza, Human.
- Cell Line, Gas Chromatography-Mass Spectrometry, Humans.
Abstract
Volatile organic compounds (VOCs) emanating from humans have the potential to revolutionize non-invasive diagnostics. Yet, little is known about how these compounds are generated by complex biological systems, and even less is known about how these compounds are reflective of a particular physiological state. In this proof-of-concept study, we examined VOCs produced directly at the cellular level from B lymphoblastoid cells upon infection with three live influenza virus subtypes: H9N2 (avian), H6N2 (avian), and H1N1 (human). Using a single cell line helped to alleviate some of the complexity and variability when studying VOC production by an entire organism, and it allowed us to discern marked differences in VOC production upon infection of the cells. The patterns of VOCs produced in response to infection were unique for each virus subtype, while several other non-specific VOCs were produced after infections with all three strains. Also, there was a specific time course of VOC release post infection. Among emitted VOCs, production of esters and other oxygenated compounds was particularly notable, and these may be attributed to increased oxidative stress resulting from infection. Elucidating VOC signatures that result from the host cells response to infection may yield an avenue for non-invasive diagnostics and therapy of influenza and other viral infections.
DOI: 10.1002/cbic.201300695
PubMed: 24719290
Affiliations:
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Le document en format XML
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Yet, little is known about how these compounds are generated by complex biological systems, and even less is known about how these compounds are reflective of a particular physiological state. In this proof-of-concept study, we examined VOCs produced directly at the cellular level from B lymphoblastoid cells upon infection with three live influenza virus subtypes: H9N2 (avian), H6N2 (avian), and H1N1 (human). Using a single cell line helped to alleviate some of the complexity and variability when studying VOC production by an entire organism, and it allowed us to discern marked differences in VOC production upon infection of the cells. The patterns of VOCs produced in response to infection were unique for each virus subtype, while several other non-specific VOCs were produced after infections with all three strains. Also, there was a specific time course of VOC release post infection. Among emitted VOCs, production of esters and other oxygenated compounds was particularly notable, and these may be attributed to increased oxidative stress resulting from infection. Elucidating VOC signatures that result from the host cells response to infection may yield an avenue for non-invasive diagnostics and therapy of influenza and other viral infections. </div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Cardona, Carol J" sort="Cardona, Carol J" uniqKey="Cardona C" first="Carol J" last="Cardona">Carol J. Cardona</name><name sortKey="Davis, Cristina E" sort="Davis, Cristina E" uniqKey="Davis C" first="Cristina E" last="Davis">Cristina E. Davis</name><name sortKey="Harper, Richart" sort="Harper, Richart" uniqKey="Harper R" first="Richart" last="Harper">Richart Harper</name><name sortKey="Sandrock, Christian E" sort="Sandrock, Christian E" uniqKey="Sandrock C" first="Christian E" last="Sandrock">Christian E. Sandrock</name><name sortKey="Sankaran, Shankar" sort="Sankaran, Shankar" uniqKey="Sankaran S" first="Shankar" last="Sankaran">Shankar Sankaran</name><name sortKey="Schivo, Michael" sort="Schivo, Michael" uniqKey="Schivo M" first="Michael" last="Schivo">Michael Schivo</name><name sortKey="Xing, Zheng" sort="Xing, Zheng" uniqKey="Xing Z" first="Zheng" last="Xing">Zheng Xing</name><name sortKey="Zhao, Weixiang" sort="Zhao, Weixiang" uniqKey="Zhao W" first="Weixiang" last="Zhao">Weixiang Zhao</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Aksenov, Alexander A" sort="Aksenov, Alexander A" uniqKey="Aksenov A" first="Alexander A" last="Aksenov">Alexander A. 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